Evaluation of Administration Prophylactic Antibiotic against Incidence of Surgical Site Infection in Post Appendectomy at Panembahan Senopati Hospital, Indonesia

Authors

DOI:

https://doi.org/10.18196/jmmr.v13i1.23

Keywords:

Antibiotic Prophylaxis, Surgical Site Infection, Appendicitis, Appendectomy

Abstract

Appendicitis is a prevalent abdominal surgical emergency in Indonesia, occurring at a rate of 5 per 1,000 people, with around 10 million cases each year. Appendectomy, the surgical removal of the vermiform, is the primary treatment for appendicitis but carries a high risk of surgical site infections. Prophylactic antibiotics are given to minimize the risk of infection resulting from surgery, administered in accordance with established guidelines. This study aims to evaluate the administration of antibiotic prophylactic against SSIs. This study used a mixed-methods approach to evaluate prophylactic antibiotic administration and the incidence of surgical site infection in post-appendectomy patients. The researchers conducted in-depth interviews with surgeons and nurses and an analytical observational study with a cross-sectional design, observing various indicators such as the timing and duration of prophylactic antibiotic administration and the presence of surgical site infections. The study found that the duration of antibiotic administration ≤24 hours had a higher number of infection-free patients (62.50%). The researchers analyzed the relationship between the duration of antibiotic administration and surgical site infection in post-appendectomy patients and found a significant relationship (p <0.05) at the hospital. There is a relationship between prophylactic antibiotic administration and surgical site infection. All patients were given prophylactic antibiotics with appropriate timing, duration, and method of administration.

References

Alamrew, K., Tadesse, T. A., Abiye, A. A., & Shibeshi, W. (2019). Surgical Antimicrobial Prophylaxis and Incidence of Surgical Site Infections at Ethiopian Tertiary-Care Teaching Hospital. Infectious Diseases: Research and Treatment, 12, 117863371989226. https://doi.org/10.1177/1178633719892267

Arini, M. (2016). Health Belief Model Pada Kepatuhan Hand Hygiene di Bangsal Berisiko Tinggi Healthcare Acquired Infections (Hais) (Studi Kasus Pada RS X). Jurnal Medicoeticolegal Dan Manajemen Rumah Sakit, 5(2). https://doi.org/10.18196/jmmr.5117

Ayele, Y., & Taye, H. (2018). Antibiotic utilization pattern for surgical site infection prophylaxis at Dil Chora Referral Hospital Surgical Ward, Dire Dawa, Eastern Ethiopia. BMC Research Notes, 11(1). https://doi.org/10.1186/s13104-018-3629-6

Bootsma, A. M. J., Laguna Pes, M. P., Geerlings, S. E., & Goossens, A. (2008). Antibiotic Prophylaxis in Urologic Procedures: A Systematic Review. European Urology, 54(6), 1270–1286. https://doi.org/10.1016/j.eururo.2008.03.033

Ceruelos, A. H., Romero-Quezada, L. C., Ledezma, J. R., & Contreras, L. L. (2019). Therapeutic uses of metronidazole and its side effects: an update. Eur Rev Med Pharmacol Sci, 23(1), 397–401.

Danwang, C., Bigna, J. J., Tochie, J. N., Mbonda, A., Mbanga, C. M., Nzalie, R. N. T., Guifo, M. L., & Essomba, A. (2020). Global incidence of surgical site infection after appendectomy: a systematic review and meta-analysis. BMJ Open, 10(2), e034266. https://doi.org/10.1136/bmjopen-2019-034266

Farizal, I., Sigit AP, S. A., & Lestari, E. S. (2016). Perbandingan Pemakaian Ceftriaxone Terhadap Infeksi Luka Operasi Pada Pasien Apendisitis Akut Non Komplikata Yang Dilakukan Laparatomi Dan Laparaskopi Apendiktomi (Doctoral dissertation, Diponegoro University).

Hastuti, S. K. W., Fadilla, A. I., & Apriansyah, S. (2021). Factors Related to Nurse Compliance in The Implementation of Universal Precaution in The Inpatient Room One of Private Hospital in Yogyakarta. JMMR (Jurnal Medicoeticolegal Dan Manajemen Rumah Sakit), 10(2), 177–188. https://doi.org/10.18196/jmmr.v10i2.10637

Kefale, B., Tegegne, G. T., Degu, A., Molla, M., & Kefale, Y. (2020). Surgical Site Infections and Prophylaxis Antibiotic Use in the Surgical Ward of Public Hospital in Western Ethiopia: A Hospital-Based Retrospective Cross-Sectional Study. Infection and Drug Resistance, Volume 13, 3627–3635. https://doi.org/10.2147/idr.s281097

Khan, Mohd. Y., Roy, M., Rawal, R. K., & Bansal, U. K. (2017). A Review-Ceftriaxone for Life. Asian Journal of Pharmaceutical Research, 7(1), 35. https://doi.org/10.5958/2231-5691.2017.00007.7

Koumu, M. I., Jawhari, A., Alghamdi, S. A., Hejazi, M. S., Alturaif, A. H., & Aldaqal, S. M. (2021). Surgical Site Infection Post-appendectomy in a Tertiary Hospital, Jeddah, Saudi Arabia. Cureus, 13(7). https://doi.org/10.7759/cureus.16187

Mulder, T., Kluytmans-van den Bergh, M. F. Q., de Smet, A. M. G. A., van ‘t Veer, N. E., Roos, D., Nikolakopoulos, S., Bonten, M. J. M., & Kluytmans, J. A. J. W. (2018). Prevention of severe infectious complications after colorectal surgery using preoperative orally administered antibiotic prophylaxis (PreCaution): study protocol for a randomized controlled trial. Trials, 19(1). https://doi.org/10.1186/s13063-018-2439-4

Mwita, J. C., Ogunleye, O. O., Olalekan, A., Kalungia, A. C., Kurdi, A., Saleem, Z., Sneddon, J., & Godman, B. (2021). Key Issues Surrounding Appropriate Antibiotic Use for Prevention of Surgical Site Infections in Low- and Middle-Income Countries: A Narrative Review and the Implications. International Journal of General Medicine, Volume 14, 515–530. https://doi.org/10.2147/ijgm.s253216

Narulita, L., Suharjono, Kuntaman, & Akram, M. (2021). Analysis of the use of antibiotics profile and factors of surgical site infections study on digestive and oncology surgeries. Journal of Basic and Clinical Physiology and Pharmacology, 32(4), 693–700. https://doi.org/10.1515/jbcpp-2020-0453

Owens, C. D., & Stoessel, K. (2008). Surgical site infections: epidemiology, microbiology and prevention. Journal of Hospital Infection, 70, 3–10. https://doi.org/10.1016/s0195-6701(08)60017-1

Prévost, N., Gaultier, A., Birgand, G., Mocquard, J., Terrien, N., Rochais, E., & Dumont, R. (2021). Compliance with antibiotic prophylaxis guidelines in surgery: Results of a targeted audit in a large-scale region-based French hospital network. Infectious Diseases Now, 51(2), 170–178. https://doi.org/10.1016/j.medmal.2020.10.005

Reichman, D. E., & Greenberg, J. A. (2009). Reducing Surgical Site Infections: A Review. Reviews in Obstetrics and Gynecology, 2(4), 212. https://doi.org/10.3909/riog0084

Richardsen, I., Schöb, D. S., Ulmer, T. F., Steinau, G., Neumann, U. P., Klink, C. D., & Lambertz, A. (2015). Etiology of Appendicitis in Children: The Role of Bacterial and Viral Pathogens. Journal of Investigative Surgery, 29(2), 74–79. https://doi.org/10.3109/08941939.2015.1065300

Saputra, A. N., Ibrahim, S. M., & Ardianto, F. W. (2022). Prevalence of Appendicitis at Surgery Inpatient Department of a Secondary Care Hospital: A Descriptive Study. International Journal of Medical Science and Clinical Research Studies, 2(10), 1059–1063. https://doi.org/10.47191/ijmscrs/v2-i10-07

Sheikh, S., Malik, N. K., & Karim, B. A. (2020). Antibiotic prophylaxis and surgical site infections; a prospective open label study to clinically evaluate the serum and tissue concentration of single dose prophylactic ceftriaxone in laparoscopic cholecystectomy. European Journal of Clinical Pharmacology, 1–6. https://doi.org/10.1007/s00228-020-02940-x

Sonda, T. B., Horumpende, P. G., Kumburu, H. H., van Zwetselaar, M., Mshana, S. E., Alifrangis, M., Lund, O., Aarestrup, F. M., Chilongola, J. O., Mmbaga, B. T., & Kibiki, G. S. (2019). Ceftriaxone use in a tertiary care hospital in Kilimanjaro, Tanzania: A need for a hospital antibiotic stewardship programme. PLOS ONE, 14(8), e0220261. https://doi.org/10.1371/journal.pone.0220261

van den Boom, A. L., de Wijkerslooth, E. M. L., & Wijnhoven, B. P. L. (2019). Systematic Review and Meta-Analysis of Postoperative Antibiotics for Patients with a Complex Appendicitis. Digestive Surgery, 37(2), 101–110. Portico. https://doi.org/10.1159/000497482

World Health Organization. (2018). Protocol for surgical site infection surveillance with a focus on settings with limited resources. Geneva: World Health Organization.

Wickramasinghe, D. P., Xavier, C., & Samarasekera, D. N. (2021). The Worldwide Epidemiology of Acute Appendicitis: An Analysis of the Global Health Data Exchange Dataset. World Journal of Surgery, 45(7), 1999–2008. https://doi.org/10.1007/s00268-021-06077-5

Downloads

Published

2024-03-22

Issue

Section

Articles